Fidelity of T Cell Activation Through Multistep T Cell Receptor Phosphorylation
β Scribed by Kersh, E. N.
- Book ID
- 121159787
- Publisher
- American Association for the Advancement of Science
- Year
- 1998
- Tongue
- English
- Weight
- 363 KB
- Volume
- 281
- Category
- Article
- ISSN
- 0036-8075
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π SIMILAR VOLUMES
he specificity of T-cell recognition events is essential for protective immune responses and in order to avoid autoimmunity. Binding of the T-cell receptor (TCR) to peptide bound to major histocompatibility complex (MHC) molecules is an early step for specific T-cell activation. This engagement lead
Antigen-specific T-cell activation requires the formation of a transient cell-cell conjugate between a T cell and an appropriate antigen presenting cell (APC). Focal aggregation of T-cell receptor (TCR) molecules at the T-cell-APC membrane interface accompanies formation of multiple non-covalent int