Fibronectin and coagulation factor XIII increases blood platelet adhesion to fibrin
β Scribed by Mogens Sandbjerg Hansen
- Book ID
- 119035497
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 444 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0049-3848
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## Abstract Von Willebrand factor (vWF), a glycoprotein in blood, mediates the adhesion of blood platelets and thus plays a crucial role in hemostasis and thrombosis. Functional coating of surfaces with vWF allows the investigation of __in vitro__ adhesion of blood platelet. We used soft lithograph
The affinities of Factor XIII (FXIII), Factor XIIIa (FXIIIa), and cellular transglutaminase (Tg) for fibrinogen (Fgn), fibrin (Fbn), and fibronectin (Fn) were compared using a solid-phase binding assay. Initial rates of binding were as follows: FXIII bound Fbn 3-fold more than Fgn. FXIII did not bin
## Abstract Four plasma proteins have been shown to be able to mediate platelet adhesion to synthetic materials when they are adsorbed as purified proteins: fibrinogen (Fg), fibronectin (Fn), vitronectin (Vn), and von Willebrand factor (vWF). Among them, Fg is thought to play a leading role in medi