Fibroblast chemotaxis and prolidase activity modulation by insulin-like growth factor II and mannose 6-phosphate
✍ Scribed by Jerzy A. Paêka; Ewa Karna; Wojciech Miltyk
- Book ID
- 110242011
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 232 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0300-8177
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The soluble form of the insulin-like growth factor II (IGF-II)/mannose 6-P (IGF-II/ M6P) receptor is released by cells in culture and circulates in the serum. It retains its ability to bind IGF-II and blocks IGF-II-stimulated DNA synthesis in isolated rat hepatocytes. Because these cells are not nor
The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act
## Abstract The mannose 6‐phosphate/insulin‐like growth factor II receptor (M6P/IGF2R) mediates biosynthetic sorting and endocytosis of various factors that impinge on the proliferation, migration and invasiveness of tumour cells. The gene encoding M6P/IGF2R is frequently lost or mutated in a wide