Secreted CREG inhibits cell proliferation mediated by mannose 6-phosphate/insulin-like growth factor II receptor in NIH3T3 fibroblasts
โ Scribed by Ya-Ling Han; Peng Guo; Ming-Yu Sun; Liang Guo; Bo Luan; Jian Kang; Cheng-Hui Yan; Shao-Hua Li
- Book ID
- 108732040
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 276 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1356-9597
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The mannose-6-phosphate/insulin-like growth factor 2 receptor (Man-6-P/IGFII receptor) is involved in lysosomal enzyme sorting, IGFII degradation and pro-TGFbeta activation. Genetic alterations in hepatocarcinomas and a few breast cancers suggest that this receptor behaves as a tumor suppressor. Mor