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Fibrinolysis associated with human neoplasia: Production of plasminogen activator by human tumours

✍ Scribed by Biserka Nagy; Jasna Ban; Branko Brdar

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
555 KB
Volume
19
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The plasminogen‐dependent fibrinolytic activity of several human tumours has been studied. The following neoplastic tissues, which were obtained from cancer patients by either surgery or biopsies, were examined: cervical, mammary, prostatic, ovarian, lung carcinomas, melanoma, basalioma. Fibrinolysis was measured in lysates either of tumour tissue specimens or of respective cell cultures. This measurement was based on release of radioactivity from ^125^I‐fibrin‐coated Petri dishes. All examined tumours showed elevated levels of plasminogen‐dependent fibrinolytic activity. However, normal control tissues had little or no activity. These results indicate that the fibrinolysis might be useful in differentiating between malignant and normal tissues.

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