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Fibrin-targeted contrast agent for improvement of in vivo acute thrombus detection with magnetic resonance imaging

✍ Scribed by Marc Sirol; Juan G.S. Aguinaldo; Philip B. Graham; Robert Weisskoff; Randy Lauffer; Gabor Mizsei; Igor Chereshnev; John T. Fallon; Ernane Reis; Valentin Fuster; Jean-François Toussaint; Zahi A. Fayad


Book ID
118420728
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
287 KB
Volume
182
Category
Article
ISSN
0021-9150

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## Abstract A preparation of ultra‐small superparamagnetic iron oxide (USPIO) particles coupled to an RGD peptide (RGD‐USPIO) was investigated as an MR contrast agent, targeted to activated platelets, in both ex vivo and in vivo thrombus models. Thrombus visualization ex vivo was compared using RGD