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Fibrin-bound lipoprotein(a) promotes plasminogen binding but inhibits fibrin degradation by plasmin

✍ Scribed by Liu, Jianning; Harpel, Peter C.; Gurewich, Victor


Book ID
126910769
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
846 KB
Volume
33
Category
Article
ISSN
0006-2960

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit