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Quantitative characterization of the binding of plasminogen to intact fibrin clots, lysine-Sepharose, and fibrin cleaved by plasmin

✍ Scribed by Bok, Robert A.; Mangel, Walter F.


Book ID
126954525
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
1006 KB
Volume
24
Category
Article
ISSN
0006-2960

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit