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FGFR3 Dimer Stabilization Due to a Single Amino Acid Pathogenic Mutation

✍ Scribed by Edwin Li; Min You; Kalina Hristova


Book ID
116662688
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
347 KB
Volume
356
Category
Article
ISSN
0022-2836

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The single DR beta chain gene of the DRw8 haplotype has been suggested to carry both the DRw8 and the DRw52 epitopes. Cellular typing has shown that the DRw8 haplotype can be split into three subtypes, Dw8.1, Dw8.2, and Dw8.3, presumably due to a polymorphism in the DRw8~ chain. Furthermore, Dw8.1 a