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FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo

✍ Scribed by C. Hafner; R. Stoehr; J.M.M. Van Oers; E.C. Zwarthoff; F. Hofstaedter; M. Landthaler; A. Hartmann; T. Vogt


Book ID
108670420
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
448 KB
Volume
160
Category
Article
ISSN
0007-0963

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Lipid kinase PIK3CA mutations have been described in several cancers. They clustered in two 'hot spots' located in helical (exon 9) and kinase (exon 20) domains associated with increased kinase activity strongly suggesting oncogenic potential. Mutational analysis of previously unexamined tumors show