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FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis

✍ Scribed by Boden, Guenther; Cheung, Peter; Stein, T. Peter; Kresge, Karen; Mozzoli, Maria


Book ID
126088778
Publisher
The American Physiological Society
Year
2002
Tongue
English
Weight
136 KB
Volume
283
Category
Article
ISSN
0193-1849

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The effect of porcine gastric inhibitory polypeptide on hepatic glycogen metabolism was investigated in the isolated in situ perfused rat liver. Glycogenolysis was stimulated by infusion of glucagon into the portal vein (half maximal effective portal vein concentration -30 pmol/1). When glucagon was