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FFA-induced hepatic insulin resistance in vivo is mediated by PKC , NADPH oxidase, and oxidative stress

✍ Scribed by Pereira, S.; Park, E.; Mori, Y.; Haber, C. A.; Han, P.; Uchida, T.; Stavar, L.; Oprescu, A. I.; Koulajian, K.; Ivovic, A.; Yu, Z.; Li, D.; Bowman, T. A.; Dewald, J.; El-Benna, J.; Brindley, D. N.; Gutierrez-Juarez, R.; Lam, T. K. T.; Najjar, S. M.; McKay, R. A.; Bhanot, S.; Fantus, I. G.; Giacca, A.


Book ID
126812155
Publisher
The American Physiological Society
Year
2014
Tongue
English
Weight
514 KB
Volume
307
Category
Article
ISSN
0193-1849

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Hepatic stellate cell activation is a main feature of liver fibrogenesis. We have previously shown that phagocytosis of apoptotic bodies by stellate cells induces procollagen ␣1 (I) and transforming growth factor beta (TGF-␀) expression in vitro. Here we have further investigated the downstream effe