Feto-maternal microchimerism in connective tissue diseases
✍ Scribed by Monique Gannagé; Zahir Amoura; Olivier Lantz; Jean-Charles Piette; Sophie Caillat-Zucman
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 158 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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The risk of cancer appears to be increased in polymyositis (PM) although not all agree with this interpretation (1-5). In other related diseases the risk is probably lower (6-9) but there has not been assessment in mixed connective tissue disease (MCTD). Since it is now possible to separate mixed co
alleles may actually operate against its formation. Alternatively, it is possible that immune response genes which promote antibodies to nRNP may not be represented on DRZlMBl/MTl and DR3/MT2 bearing haplotypes. Thus, the presence of both sets of alleles, as seen in our patients, might exclude this