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Fetal outcome and childhood mortality in offspring of mothers with sickle cell trait and disease

✍ Scribed by R. S. Balgir; B. P. Dash; R. K. Das


Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
384 KB
Volume
64
Category
Article
ISSN
0019-5456

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Variation in the level of fetal hemoglobin (HbF) accounts for much of the clinical heterogeneity observed in patients with sickle cell disease (SCD). The HbF level has emerged as an important prognostic factor in both sickle cell pain and mortality, and a % HbF of 10-20% has been suggested as a thre

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## Abstract A natural history study was conducted in 142 Thalassemic (Thal), 199 transfused Sickle Cell Disease (Tx‐SCD, __n__ = 199), and 64 non‐Tx‐SCD subjects to describe the frequency of iron‐related morbidity and mortality. Subjects recruited from 31 centers in the US, Canada or the UK were si