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Festphasensynthese vonO-Glycopeptiden

✍ Scribed by Paulsen, Hans ;Merz, Gunnar ;Peters, Stefan ;Weichert, Udo

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
950 KB
Volume
1990
Category
Article
ISSN
0947-3440

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✦ Synopsis

Solid Phase Synthesis of O‐Glycopeptides

The solid phase synthesis of a number of O‐glycopeptides are described. A polystyrene resin containing p‐alkoxybenzyl alcohol groups was used as support. Glycosylamino acids of 2‐acetamido‐2‐deoxy‐D‐galactose and threonin or serin can be coupled with further amino acids and also with other glycosylated amino acids. The introduction of disaccharide‐containing amino acids gives uncomplete reaction. The final cleavage from the carrier and the deprotection present no difficulties. Partial structures of the ovine submaxillary mucin and of human and porcine glycophorin are prepared.

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