Ferrocenyliminophosphites as Easy-to-Modify Ligands for Asymmetric Catalysis

✍ Scribed by Konstantin N. Gavrilov; Marina G. Maksimova; Sergey V. Zheglov; Oleg G. Bondarev; Eduard B. Benetsky; Sergey E. Lyubimov; Pavel V. Petrovskii; Anzhelika A. Kabro; Evamarie Hey-Hawkins; Sergey K. Moiseev; Valery N. Kalinin; Vadim A. Davankov

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 176 KB
• Volume: 2007
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200700396

✦ Synopsis

Abstract

Several N,P bidentate phosphite‐type ligands derived from readily available ferrocene‐based iminoalcohols were successfully used in Rh‐catalysed hydrogenations and Pd‐catalysed allylic substitutions of a variety of substrates. Moderate‐to‐high catalytic activities under standard conditions were observed, and the enantiomeric excess of the products were up to 97 %. Results obtained under systematic variation of the ligand parameters indicate that the enantioselectivity is largely determined by the nature of the phosphocentre and also by the substituent in the C*HN‐fragment. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)