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Ferrocene-Assisted Stabilization of Collagen Mimetic Triple Helices: Solid-Phase Synthesis and Structure

✍ Scribed by Dey, Subrata K.; Kraatz, Heinz-Bernhard


Book ID
126299949
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
283 KB
Volume
17
Category
Article
ISSN
1043-1802

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The triple-helical conformation of collagen has been proposed to be important for mediation of cellular activities, such as adhesion and activation, extracellular matrix assembly, and enzyme function. We have developed synthetic protocols that allow for the study of biological activities of specific

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## Abstract As model peptides of collagen, (Pro‐Pro‐Gly)~__n__~ (__n__ = 10, 12, 14, and 15) and (Pro‐Pro‐Gly)~__n__~(Ala‐Pro‐Gly)~__m__~(Pro‐Pro‐Gly)~__n__~ (2__n__ + __m__ = 15; __m__ = 1, 3, and 5) were synthesized by the solid‐phase method. The final products were pure when checked by high‐volt