Ferritin in erythrocytes and plasma of patients with iron overload
✍ Scribed by Bodemann, H. H. ;Tanzi-Fetta, R. F. ;Schr�ter-Urban, H. ;Volk, B. A. ;Keul, J. ;L�hr, G. W.
- Publisher
- Springer-Verlag
- Year
- 1985
- Weight
- 365 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1432-0584
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Ferritin-like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electron probe microanalysis detecting the presence of the elements iron and
After a single subcutaneous dose of iron-dextran (600 mg of ironkg), iron overload developed in CS7BL/lOScSn mice. At 4,24 and 78 wk liver nonheme iron concentrations were 67-, 42-and 21-fold higher than controls, respectively. Much of the iron was in macrophages, but hepatocytes were also strongly