Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol

✍ Scribed by M. Kiese; L. Szinicz; N. Thiel; N. Weger

• Book ID: 104736586
• Publisher: Springer-Verlag
• Year: 1975
• Tongue: English
• Weight: 243 KB
• Volume: 34
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00353854

✦ Synopsis

4-Dimethylaminophenol hydrochloride (DMAP), 20mg/kg i.v., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400 mg/kg i.v., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.