Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

Ameliorative effects of a neuroprotectiv

Ameliorative effects of a neuroprotective agent, T-817MA, on place learning deficits induced by continuous infusion of amyloid-β peptide (1–40) in rats

✍ Phuong Thi Hong Nguyen; Tatsuo Kimura; Son Anh Ho; Anh Hai Tran; Taketoshi Ono; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 985 KB

## Abstract Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline due to neuronal loss and neural network dysfunction. It has been postulated that progressive neuronal loss in AD is consequence of the neurotoxic properties of the amyloid‐β peptide (Aβ). In the p