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Ferric chloride in acetic anhydide. Mild and versatile reagent for the cleavage of ethers

โœ Scribed by Ganem, Bruce; Small, Vernon R.


Book ID
111926673
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
456 KB
Volume
39
Category
Article
ISSN
0022-3263

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A novel method for the preparation of 1,6-anhydro glucopyranoses (mono-and disaccharides) utilizing anhydrous FeCl 3 as Lewis acid is described. Treatment of methyl 6-O-benzyl and 6-O-p-methoxybenzyl-a/b D-glucopyranosides derivatives with FeCl 3 in CH 2 Cl 2 at room temperature and 40ยฐC afforded 1,