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Fermentation monitoring and control by on-line flow injection and liquid chromatography

✍ Scribed by K Schügerl; L Brandes; T Dullau; K Holzhauer-Rieger; S Hotop; U Hübner; X Wu; W Zhou

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
784 KB
Volume
249
Category
Article
ISSN
0003-2670

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✦ Synopsis

The on-line use of flow-injection analysis to determine monosaccharides and disaccharides (in the presence and absence of glucose), lactate, ammo acids and glutamine during the production of alkaline protease and penicillin and their use in process control are reported. The results of the use of on-line and off-line liquid chromatography in the determination of cephalosporins, penicillins, carbohydrates, carboxylic and amino acids and inorganic anions during the production of extracellular enzymes by bacteria, intracellular fusion proteins by means of recombinant bacteria and antibiotics by fungi and their use in process control are also reported.

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