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Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

✍ Scribed by Roos Cuperus; René Leen; Godelieve A. M. Tytgat; Huib N. Caron; André B. P. van Kuilenburg

Publisher
Springer
Year
2009
Tongue
English
Weight
400 KB
Volume
67
Category
Article
ISSN
1420-682X

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## Abstract Cyclosporin A (CyA), a potent immunosuppressant, was used to determine the hepatotoxic effect in long‐term treatments. Male Wistar rats were used in these experiments. They were given CyA chronically at doses used in patients for 120 days, and at doses of 5, 10, 15 and 20 mg kg^−1^ day^