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Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

โœ Scribed by Jincai Li; Chun Loong Wong; Natarajan Vijayasankaran; Terry Hudson; Ashraf Amanullah

Book ID
112012764
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
540 KB
Volume
109
Category
Article
ISSN
0006-3592

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As we pursue the means to improve yields to meet growing therapy demands, it is important to examine the impact of process control on glycosylation patterns to ensure product efficacy and consistency. In this study, we describe a dynamic on-line fed-batch strategy based on low glutamine/glucose conc