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Feedforward inhibition in biosynthetic pathways: inhibition of the aminoacyl-tRNA synthetase by intermediates of the pathway

✍ Scribed by Michael A. Savageau; Gerald Jacknow


Book ID
107823341
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
933 KB
Volume
77
Category
Article
ISSN
0022-5193

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The incubation of human platelets with methylglyoxal and glucose produces a rapid transformation of the ketoaldehyde to D-lactate by the glyoxalase system and a partial reduction in GSH. Glucose utilization is affected at the level of the glycolytic pathway. No effect of the ketoaldehyde on glycogen