𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Feedback regulation of bile acid synthesis in human liver: Importance of HNF-4α for regulation of CYP7A1

✍ Scribed by Anna Abrahamsson; Ulf Gustafsson; Ewa Ellis; Lisa-Mari Nilsson; Staffan Sahlin; Ingemar Björkhem; Curt Einarsson


Book ID
116290189
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
287 KB
Volume
330
Category
Article
ISSN
0006-291X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Glucagon and cAMP inhibit cholesterol 7α
✍ Kwang-Hoon Song; John Y. L. Chiang 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

The gene encoding cholesterol 7␣-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind

In vivo regulation of murine CYP7A1 by H
✍ Minhua Wang; Yongjun Tan; Robert H. Costa; Ai-Xuan L. Holterman 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 303 KB

Disruption of the enterohepatic bile acid circulation during biliary tract obstruction leads to profound perturbation of the cholesterol and bile acid metabolic pathways. Several families of nuclear receptor proteins have been shown to modulate this critical process by regulating hepatic cholesterol

Liver receptor homolog-1 is critical for
✍ Carolien Out; Jurre Hageman; Vincent W. Bloks; Han Gerrits; Maarten D. Sollewijn 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

Liver receptor homolog-1 (LRH-1) is a nuclear receptor that controls a variety of metabolic pathways. In cultured cells, LRH-1 induces the expression of CYP7A1 and CYP8B1, key enzymes in bile salt synthesis. However, hepatic Cyp7a1 mRNA levels were not reduced upon hepatocyte-specific Lrh-1 deletion