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VOLUME 110 โข NUMBER 4 ## FEATURES Cytology is the fi eld of medicine in which various morphologic "criteria of malignancy" are applied to individual cells and small tissue fragments to diagnose cancer. Surprisingly little is known about the molecular basis of many of these defi ning structural fe
VOLUME 110 โข NUMBER 5 ## FEATURES A hallmark of acute myeloid leukemias (AMLs) is the presence of recurrent chromosomal rearrangements. Two common rearrangments, inv(16) and t(8;21), generate fusion genes with members of the Core Binding Factor (CBF) family of transcription factors, CBFB and RUNX
RUNX2 plays important roles in bone development by regulating the differentiation of osteoblasts and chondrocytes. The major issue is how RUNX2 regulates differentiation of the two different lineages at an appropriate time and space during bone development. Komori proposes that reciprocal regulation
Rad9 protein is best known for its roles in cell cycle checkpoints and DNA repair as part of the Rad9-Hus1-Rad1 (9-1-1) complex, which has a critical function in maintaining genomic stability. Rad9, however, has additional roles unrelated to 9-1-1. Recent studies indicate that the protein can specif