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Features of trinucleotide repeat instability in vivo

✍ Scribed by Kovtun, Irina V; McMurray, Cynthia T

Book ID
109846897
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
843 KB
Volume
18
Category
Article
ISSN
0007-0610

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The fragile sites FRAXA and FRAXE, located ∼600 kb apart on Xq27.3 and Xq28, respectively, are due to a CGG trinucleotide repeat expansion. Although the expansion mechanism for these and other trinucleotide repeat disorders remains unknown, the similarities between the FRAXA and FRAXE regions sugges