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Feasibility of proposed single-nucleotide polymorphisms as predictive markers for targeted regimens in metastatic colorectal cancer

✍ Scribed by Kim, J C; Ha, Y J; Roh, S A; Choi, E Y; Yoon, Y S; Kim, K P; Hong, Y S; Kim, T W; Cho, D H; Kim, S Y; Kim, Y S

Book ID
120326080
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
896 KB
Volume
108
Category
Article
ISSN
0007-0920

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has