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Faster non-renal clearance of metoprolol in streptozotocin-induced diabetes mellitus rats

✍ Scribed by Lee, Unji; Lee, Inchul; Lee, Byung K.; Kang, Hee E.

Book ID
123113358
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
387 KB
Volume
50
Category
Article
ISSN
0928-0987

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## Abstract The pharmacokinetic parameters of 5‐fluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control Sprague–Dawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS). In DMIS rats, the area under the plasma concentration–time curve from