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Fast perfluorocarbon imaging using 19F U-FLARE

✍ Scribed by P. Börnert; D. G. Norris; H. Koch; W. Dreher; H. Reichelt; D. Leibfritz

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
996 KB
Volume
29
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The application of an ultra‐fast low angle RARE technique for the ^19^F imaging of perfluorocarbons (PFCs) used as temporary blood substitutes is described. This sequence is attractive for fast ^19^F imaging studies that measure the biodistribution of PFCs in vivo, due to its high signal‐to‐noise ratio. Extensions of this technique for the chemical shift selective measurement of fluorine T~1~ values are presented. Using the linear dependence between the oxygen partial pressure (pO~2~) and the T~1~ relaxation rate of PFC resonances this technique makes possible the fast in vivo measurement of oxygen tension. Using the sequence in a diffusion sensitized form ^19^F measurements of the diffusion constants of PFCs are also presented. Phantom experiments to test the methods, and in vivo images obtained in rat studies are given and discussed.

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