Fast chemical synthesis of [75Sel-selenomethionine

✍ Scribed by A. Plenevaux; R. Cantineau; M. Guillaume; L. Christiaens; G. Tihange

• Book ID: 103919998
• Publisher: Elsevier Science
• Year: 1987
• Weight: 202 KB
• Volume: 38
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(87)90237-1

✦ Synopsis

A fast chemical synthesis of high specific activity [75Se]L-selenomethionine (10 Ci/mmol--370 GBq/mmol) is described with a view to 73Se labeling and PET studies. The overall radiochemical yield of the preparation is better than 80%. The purification method uses commercially available reverse phase HPLC columns and 9% NaCl as mobile phase. The final labeled compound is obtained in less than 3 h and the chemical, radiochemical and optical purities of the L-isomer are higher than 99.0%.