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Fast atom bombardment-promoted reductive ring opening of 1,2-benzisothiazoles

✍ Scribed by Thomas R. Sharp; John F. Lambert; Stanley W. Walinsky

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 147 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00166-7

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✦ Synopsis

Fast atom bombardment mass spectral examination of molecules containing a 1,2-benzisothiazole ring, using a thiol reducing agent matrix, promotes reductive ring opening of the benzisothiazole ring, giving an [M+H] + two daltons higher than expected. Measurements using a non-reducing matrix produce the expected [M+H] + . This is a general phenomenon, observed with a number of molecules containing the benzisothiazole ring. The ring-opened structure has been confirmed by chemical synthesis and observed in metabolic studies.

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