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Fast atom bombardment mass spectrometry of some anthracycline and bisanthracycline derivatives

✍ Scribed by Christopher J. Chandler; Robert T. C. Brownlee; Robert J. Hook; Don R. Phillips; James A. Reiss; John A. Edgar

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
388 KB
Volume
17
Category
Article
ISSN
1076-5174

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✦ Synopsis

Fast atom bombardment (FAB) mass spectra of daunomycin (l), four of its derivatives (2-3, seven bisanthracyclines (6-12) and three mixed-functional daunomycin-acridine derivatives (13-15) are reported. These anthracyclines all exhibited their expected [MH]' ions and peaks corresponding to the fragmentations which are characteristic of the anthracycline moiety, and in addition the spectra showed enhanced [MH + n]+ (n = 1-4) ions which were attributed to reductive processes occurring in the liquid matrix under FAB conditions. Daunomycin was also observed to form a dimeric cluster ion [M,H)+ together with associated reduced ions under FAB conditions. We have found that FAB mass spectrometry is an ideal method for the qualitative analysis of large, non-volatile derivatives of anthracyclines.

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