Fast Atom Bombardment Mass Spectrometry for the Characterization of Taxanes

✍ Scribed by Madhusudanan, K. P.; Chattopadhyay, S. K.; Saha, G. C.; Kulshrestha, M.; Sharma, R. P.; Kumar, Sushil

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 622 KB
• Volume: 32
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/(sici)1096-9888(199702)32:2<216::aid-jms473>3.0.co;2-s

✦ Synopsis

Fast atom bombardment mass spectrometry (FABMS) of several taxanes and 11(15 Ç 1)abeo-taxanes having a 4(20)-exocyclic methylene group or oxetane ring was studied in detail using collision-induced dissociation (CID) of their

and ions. The results indicate that FAB followed by MS/MS is a [ M + NH 4 ] ' valuable tool for the identiÐcation of functional groups in taxanes and to some extent the type of taxane under investigation. The presence of hydroxy groups in the molecule is best conÐrmed by examining the CID of the adduct ions. The 11(15 Ç 1)abeo-taxanes are characterized by elimination of the hydroxy-[ M + NH 4 ] ' isopropylidene group with an acetoxy or benzoyloxy group. 1997 by