Fast and Chemoselective Transfer Hydrogenation of Aldehydes Catalyzed by a Terdentate CNN Ruthenium Complex [RuCl(CNN)(dppb)]

✍ Scribed by Walter Baratta; Katia Siega; Pierluigi Rigo

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 81 KB
• Volume: 349
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200700014

✦ Synopsis

Abstract

Aromatic, aliphatic and α,β‐unsaturated aldehydes are quickly, quantitatively and chemoselectively reduced to primary alcohols with 2‐propanol using 0.05–0.01 mol % of the terdentate CNN ruthenium complex RuCl(CNN)(dppb) (1) [HCNN=6‐(4′‐methylphenyl)‐2‐pyridylmethylamine; dppb=Ph~2~P(CH~2~)~4~PPh~2~] in the presence of potassium carbonate (K~2~CO~3~; 1–10 mol %) as a weak base, affording TOF values up to 5.0×10^5^ h^−1^.