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Fast algorithm for peptide sequencing by mass spectroscopy

✍ Scribed by Christian Bartels

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
435 KB
Volume
19
Category
Article
ISSN
1076-5174

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✦ Synopsis

An automatic algorithm for sequencing polypeptides from fast atom bombardment tandem mass spectra is presented. Based on graph theory considerations it finds the most probable sequences, even if the amino acid composition is unknown, by scoring mass differences. The algorithm is fast as the computing time increases by less than the square of the number of amino acids. Pairs of two or three amino acids are proposed to explain the gap if peaks are missing.

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