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Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes

✍ Scribed by S. Meini, P. Cucchi, L. Tinti, S. Niccolini, F. Bellucci, C. Catalani, C. Valenti, M. Galeazzi, A. Fioravanti, C. A. Maggi


Book ID
113021519
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
311 KB
Volume
385
Category
Article
ISSN
0028-1298

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## Abstract ## Objective To elucidate the mechanism of basic calcium phosphate (BCP) crystal–induced prostaglandin E~2~ (PGE~2~) production in human foreskin fibroblasts (HFFs), to identify the signaling pathway involved in the induction of cyclooxygenase 2 (COX‐2) messenger RNA (mRNA) by BCP crys