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Farnesylated proteins and cell cycle progression

✍ Scribed by Fuyuhiko Tamanoi; Juran Kato-Stankiewicz; Chen Jiang; Iara Machado; Nitika Thapar

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 93 KB
Volume: 84
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10067

No coin nor oath required. For personal study only.

✦ Synopsis

Post-translational modi®cation of proteins by the addition of a farnesyl group is critical for the function of a number of proteins involved in signal transduction. Farnesylation facilitates their membrane association and also promotes protein±protein interaction. Recently, progress has been made in understanding the biological signi®cance of farnesylation. First, effects of farnesyltransferase inhibitors (FTIs) on cancer cells have been examined using a variety of human cancer cells. This study showed that one of the major effects of FTIs is to alter cell cycle progression. Both G0/G1 enrichment and G2/M accumulation were observed depending on the cell line examined. Second, a number of novel farnesylated proteins have been characterized. Of these, Rheb and CENP-E,F are of particular interest. Rheb, a novel member of the Ras superfamily G-proteins, may play a role in the G1 phase of the cell cycle. CENP-E,F are centromere associated motors that play critical roles in mitosis. These results suggest important contributions of farnesylated proteins in the regulation of cell cycle progression.

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