Family organization of mouseH-2class I genes
β Scribed by John H. Rogers
- Book ID
- 104770996
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 777 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0093-7711
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β¦ Synopsis
The H-2 complex of the mouse contains numerous class I genes of unknown function. These genes are here classified into families according to homology in the exons encoding the variable domains. There are one major and at least five minor families, whose members are partly clustered and partly interspersed on the mouse chromosome. DNA sequences show that not only Tla and Qa-2 but also other minor-family genes have intact coding domains. These may be expressible genes of novel types. ' ' . d ' ' d ' . ' .' ' ' .
π SIMILAR VOLUMES
DNA was isolated from 75 mouse strains carrying classical H-2 haplotypes as well as haplotypes derived from wild mice. The DNA was digested with three restriction endonucleases, Bst EII, Eco RI, and Bam HI, the digests hybridized, using the Southern blotting technique, with probes for the class II g