Family history characteristics, tumor microsatellite instability and germlineMSH2andMLH1mutations in hereditary colorectal cancer
β Scribed by B. V. Bapat; Lisa Madlensky; Larissa K. F. Temple; T. Hiruki; Mark Redston; David L. Baron; Ling Xia; Victoria A. Marcus; Claudio Soravia; Angela Mitri; Wesley Shen; Robert Gryfe; Theresa Berk; Bernard N. Chodirker; Zane Cohen; Steven Gallinger
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 103 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0340-6717
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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
## Genetic diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC ) may have a significant impact on the clinical management of patients and their at-risk relatives. At present, clinical criteria represent the simplest and most useful method for the identification of HNPCC families and for
Hereditary non-polyposis colorectal cancer (HNPCC), the most common hereditary colon cancer syndrome, is a dominant disorder caused by germline defects in mismatch repair (MMR) genes. Identification of MMR gene mutations can have direct clinical implications in counseling and management of HNPCC fam
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