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Familial nonrandom inactivation linked to the X inactivation centre in heterozygotes manifesting haemophilia A

✍ Scribed by Bicocchi, Maria Patrizia; Migeon, Barbara R; Pasino, Mirella; Lanza, Tiziana; Bottini, Federico; Boeri, Elio; Molinari, Angelo C; Corsolini, Fabio; Morerio, Cristina; Acquila, Maura


Book ID
110026190
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
117 KB
Volume
13
Category
Article
ISSN
1018-4813

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DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whethe