Familial mixed tumors of the parotid gland

✍ Scribed by Min S. Ahn; Grant M. Hayashi; Raymond L. Hilsinger Jr.; Anil K. Lalwani

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 350 KB
• Volume: 21
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/(sici)1097-0347(199912)21:8<772::aid-hed14>3.0.co;2-p

✦ Synopsis

Background. The most common neoplasm of the parotid gland is the pleomorphic adenoma. The familial occurrence of such tumors arising within the parotid gland is rare, with only 3 previous reports in the literature. Bilateral synchronous pleomorphic adenomas of the parotid gland are also uncommon. We report 2 siblings with pleomorphic adenomas of the parotid gland, 1 of whom had bilateral synchronous mixed tumors.

Patients and Methods. Chromosomal analysis of tumor cells from the sibling with bilateral adenomas revealed the translocation t(3;12)(p21;q15). Chromosome 12q breakpoints have previously been identified in a wide variety of solid tumors including pleomorphic adenomas of the parotid gland.

Conclusions. We discuss bilateral mixed tumors, familial parotid tumors, and the potential for a genetic predisposition for the recurrence of such parotid tumors, as suggested by characteristic chromosomal translocations associated with mixed tumors