Familial cutaneous melanoma and two-mutational-event modeling
β Scribed by Daniella Duke; J. Castresana; Lesley Lucchina; Tom H. Lee; Arthur J. Sober; William P. Carey; D. E. Elder; Raymond L. Barnhill
- Book ID
- 101330466
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 469 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Background. Excessive risk of cutaneous melanoma as a second cancer has been associated with benign or malignant tumors of the nervous system. Cutaneous melanoma and nervous system tumors may independently aggregate in families. There are, however, no previous reports of increased likelihood of tumo
## Abstract __CDKN2A__ is a major susceptibility gene for cutaneous malignant melanoma (CMM), but the variable penetrance and clinical manifestations among mutation carriers suggest the existence of modifier factors. The goal of this study was to identify modifier genes for CMM in CMMβprone familie