✦ LIBER ✦

CDKN2A mutations in Scottish families with cutaneous melanoma: results from 32 newly identified families

✍ Scribed by J. Lang; M. Boxer; R.M. MacKie

Book ID: 108668406
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 133 KB
Volume: 153
Category: Article
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2005.06846.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

CDKN2A mutations in melanoma families fr

CDKN2A mutations in melanoma families from Uruguay

✍ A.L. Borges; F. Cuéllar; J.A. Puig-Butillé; M. Scarone; L. Delgado; C. Badenas; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

Identification of modifier genes for cut

Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations

✍ Xiaohong Rose Yang; Ruth M. Pfeiffer; William Wheeler; Meredith Yeager; Stephen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB

## Abstract __CDKN2A__ is a major susceptibility gene for cutaneous malignant melanoma (CMM), but the variable penetrance and clinical manifestations among mutation carriers suggest the existence of modifier factors. The goal of this study was to identify modifier genes for CMM in CMM‐prone familie

Novel CDKN2A Mutations Detected in Weste

Novel CDKN2A Mutations Detected in Western Swedish Families with Hereditary Malignant Melanoma

✍ Erlandson, Anna; Appelqvist, Frida; Wennberg, Ann-Marie; Holm, Joanna; Enerbäck, 📂 Article 📅 2007 🏛 Nature Publishing Group 🌐 English ⚖ 118 KB

Genetic variants in DNA repair genes and

Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations

✍ Xueying Sharon Liang; Ruth M. Pfeiffer; William Wheeler; Dennis Maeder; Laurie B 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 846 KB

## Abstract Cutaneous malignant melanoma (CMM) is an etiologically heterogeneous disease with genetic, environmental (sun exposure) and host (pigmentation/nevi) factors and their interactions contributing to risk. Genetic variants in DNA repair genes may be particularly important since their altere

Functional, structural, and genetic eval

Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients

✍ Caroline Kannengiesser; Sharon Brookes; Anna Gutierrez del Arroyo; Danielle Pham 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 392 KB 👁 1 views

Germline mutations of the CDKN2A gene are found in melanoma-prone families and individuals with multiple sporadic melanomas. The encoded protein, p16(INK4A), comprises four ankyrin-type repeats, and the mutations, most of which are missense and occur throughout the entire coding region, can disrupt

Affected members of melanoma-prone famil

Affected members of melanoma-prone families with linkage to 9p21 but lacking mutations in CDKN2A do not harbor mutations in the coding regions of either CDKN2B or p19ARF

✍ Ling Liu; Alisa M. Goldstein; Margaret A. Tucker; Herbert Brill; Nelleke A. Grui 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB 👁 2 views

Mutations in the gene encoding the cell cycle inhibitor CDKN2A have been identified in some melanoma kindreds linked to 9p21. However, many such families show no evidence of mutations in the coding regions of CDKN2A. In this study, we examined whether two other potential tumor suppressors, CDKN2B an