✦ LIBER ✦

Familial analysis of qualitative traits under multifactorial inheritance

✍ Scribed by Dr. John Rice; Theodore Reich; R. C. Elston

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 942 KB
Volume: 2
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370020307

No coin nor oath required. For personal study only.

✦ Synopsis

The analysis of family data is described for qualitative multifactorial traits. For such a trait, affectational status is determined by an underlying liability distribution with one or more thresholds. The distribution of families (either selected at random or through probands) is used to estimate sex-specific parent-offspring and sibling correlations in liability and the prevalence in each sex. In contrast to using pairs of relatives, this approach permits estimation of age-specific population prevalences without a control sample. Moreover, by allowing for sex-specific correlations and a correlation between mates, path analysis can be used to model and test various cultural transmission models in addition to polygenic inheritance. Parameter estimation, hypothesis testing, and a goodness-of-fit test for path analytic models are described, and a computer program implementing these procedures is outlined.

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