Fall risk and gait in Parkinson's disease: The role of the LRRK2 G2019S mutation
β Scribed by Mirelman, Anat; Heman, Talia; Yasinovsky, Kira; Thaler, Avner; Gurevich, Tanya; Marder, Karen; Bressman, Susan; Bar-Shira, Anat; Orr-Urtreger, Avi; Giladi, Nir; Hausdorff, Jeffrey M.
- Book ID
- 121397500
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 932 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0885-3185
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## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucineβrich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester
## Abstract Leucine rich repeat kinase (__LRRK2__) G2019S mutations are presumed to cause PD through a toxic gain of function of the protein kinase. Small molecule kinase inhibitors have been developed for the treatment of certain cancers, and some antioncogenic agents such as sunitinib, may nonspe