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Failure to prolong pancreatic islet allograft survival in rats with donor-specific blood transfusions and immunosuppression

✍ Scribed by J. Adam Vliet; Lieuwe G. Hem; M. Jane Field; David E. R. Sutherland

Publisher: Springer
Year: 1988
Tongue: English
Weight: 351 KB
Volume: 1
Category: Article
ISSN: 0934-0874
DOI: 10.1007/bf00348837

No coin nor oath required. For personal study only.

✦ Synopsis

The effects on pancreatic islet allograft survival of donor-specific blood transfusions (DST) in combination with pre-and posttransplant immunosuppression were studied. A total of 12 groups of rats (n=105) with chemically induced diabetes underwent islet allotransplantation. Multiple DST or third-party blood transfusions (TPT) were given prior to transplantation. Pretransplant immunosuppression consisted of azathioprine and prednisolone, and low-dose cyclosporinA was used for posttransplant immunosuppression. TPT, as well as separate or combined pre-and posttransplant immunosuppression without blood transfusions, did not prolong islet allograft survival. DST resulted in either primary nonfunction of the islet allografts or a markedly decreased islet allograft survival. These findings contrast with the beneficial effect of DST on whole-organ allograft survival in rats previously described by others.

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