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Failure of sister chromatid separation leads to formation of diplochromosomes in colcemid treated PtK1 cells

โœ Scribed by Sibdas Ghosh; Neidhard Paweletz; Dieter Schroeter

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
226 KB
Volume
17
Category
Article
ISSN
1065-6995

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โœฆ Synopsis

Abstract

The origin of diplochromosomes has been traced in multinucleate rat kangaroo cells (PtK1) obtained after colcemid treatment. In these cells the diplochromosomes were shown to originate from restitution nuclei, indicating that they were formed due to the omission or failure of sister chromatid separation and not due to endoreduplication. In this context the mechanism of sister chromatid separation has been discussed. The independence of this mitotic event from other associated processes, such as chromosome condensation, nuclear envelope breakdown or spindle formation has been stressed.

๐Ÿ“œ SIMILAR VOLUMES

Failure of centromere separation leads t
Failure of centromere separation leads to formation of diplochromosomes in next mitosis in okadaic acid treated HeLa cells.
โœ Sibdas Ghosh; Neidhard Paweletz; Dieter Schroeter ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 260 KB

## Abstract High concentrations of okadaic acid, sufficient to inhibit phosphatase 1 and 2A activities, induces formation of diplochromosomes in HeLa cells. It has been shown that this is due to a failure of sister chromatid separation in earlier mitosis in the presence of okadaic acid in the mediu