Fadrozole: A Potent and Specific Inhibitor of Aromatase in the Zebra Finch Brain
โ Scribed by Juli Wade; Barney A. Schlinger; Lynn Hodges; Arthur P. Arnold
- Book ID
- 112245718
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 393 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0016-6480
No coin nor oath required. For personal study only.
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In songbirds, aromatase (estrogen synthase) activity and mRNA are readily detectable in the brain. This neural aromatization presumably provides estrogen to steroid-sensitive targets via autocrine, paracrine, and synaptic mechanisms. The location of immunoreactive protein, however, has been difficul
## Background: Fadrozole hydrochloride (cgs 16949a) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. circulating estradiol, estrone, and